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Neuropathological investigations in the substantia nigra pars compacta of Parkinsons disease patients demonstrate that deficient PGC-1 expression compromises mitochondrial biogenesis and disrupts the coordinated transcriptional activation of antioxidant stress-responsive gene networks, thereby precipitating dopaminergic neuronal degeneration (Piccinin et al., 2021)

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Traveler's cases affect 20-40% of international visitors, primarily from contaminated water and foodtake bismuth subsalicylate (525mg every 30 minutes for up to 8 doses) for mild symptoms