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Although originally identified as a beta cell G-protein-coupled receptor linked to the glucose-dependent stimulation of insulin secretion (Fig

found that PA (100 mgkg-1) attenuated EtOH-induced liver injury and inhibited the levels of SREBP-1c, TNF-, IL-6 and IL-1, and mechanistically, PA might suppress liver lipid accumulation and inflammation by regulating MMP8 (Li et al., 2024)

doi: 10.1038/s41575-025-01075-7

The ATTAIN program encompasses multiple Phase 3 trials in obesity (ATTAIN-1, ATTAIN-2, ATTAIN-3, ATTAIN-MAINTAIN), while the ACHIEVE program covers type 2 diabetes indications (ACHIEVE-1 through ACHIEVE-5, plus regional studies)