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Importantly, these metabolic abnormalities confer independent cardiovascular risk, underscoring that metabolic dysfunction is a separate, powerful driver of chronic disease, and not simply a consequence of excess body weight

Of the monitored tryptophan metabolites, only 5-hydroxyindolacetic acid was positively correlated with the severity of depression, total cholesterol, and negatively with brain-derived neurotrophic factor and glutathione peroxidase

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Eli Lilly plans to submit the daily orforglipron pill for global regulatory approval by the end of 2025, joining competitor Novo Nordisk, which is also seeking approval for an oral version of its Wegovy semaglutide medication