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The immune system is trained in the gut
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suggests that a key element in this process involves the activation of G-proteins, which are closely associated with the inner surface of the cell membrane and activate downstream pathways leading to the production of secondary messengers such as cyclic adenosine monophosphate (cAMP) and inositol triphosphate (IP3)
These metabolites, along with others like prostaglandin E2 (PGE2) and eicosanoids, play a pivotal role in the immunosuppressive functions of MDSCs within the tumor microenvironment [39]
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