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Antibody formation against Sermorelin can theoretically occur with chronic use, potentially reducing efficacy, though clinical significance appears limited

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For those with persistent closed comedones, consulting a dermatologist may provide access to more advanced treatments, such as chemical peels or microdermabrasion, which can further help in managing and preventing their recurrence

Main benefits include unprecedented weight loss averaging 25% of total body weight (about 60 pounds for a 240-pound personal), superior to any other weight loss medication and approaching surgical results