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Specifically, in the group aged 50 and above, the association between serum cotinine and testosterone demonstrated a significant nonlinear relationship, where testosterone levels decreased as serum cotinine increased when serum cotinine concentration exceeded 508 ng/ml

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Users may expose themselves to potentially toxic levels of nicotine during the process of refilling them

CYP1A1 metabolic activity has also been shown to be increased by approximately 66%70% in smokers, mainly due to exposure to aryl hydrocarbons such as benzo [a]pyrene (Vistisen, Loft, and Poulsen, 1991)