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Funding This research was partially supported by and performed within the framework of the Top Institute Pharma project T1-201 COPD, transition of systemic inflammation into multi-organ pathology, with partners University Medical Center Groningen, University Medical Center Utrecht, University Medical Center Maastricht, Nycomed BV, GlaxoSmithKline, Danone, AstraZeneca, and Foundation TI Pharma

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