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They contradicted statements made by the tobacco CEOs, for example, that nicotine was kept in tobacco simply for the flavor rather than for its addictive impact.[13] They showed evidence from their experiments that when rats were taught to press a lever to receive an injection of nicotine, they increasingly did so, demonstrating not only addictive behavior, but also how users build up nicotine tolerance over time.[14] A few days after the hearing, the subcommittee obtained documents from a public relations firm retained by the tobacco industrys trade association to combat anti-tobacco criticism and legislation

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This heterogeneity regards the e-cigarette products, the biological models, the exposure systems, and also the doses used