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A vape kit is a battery-operated device designed to create vapour by heating a flavoured liquid, commonly known as e-liquid or vape juice

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Following the same search strategy and inclusion criteria as a previous meta-analysis 1,2 , we updated the literature search in 14 databases from the last search date, 1 January to 20 October 2025, and identified an additional 405 studies for eligibility screening

There is no screening test for tertiary disease in patients previously diagnosed with primary or secondary syphilis, but a cerebrospinal fluid (CSF) examination is recommended if neurologic or ocular manifestations are present