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One study found that smokers burn through an average of $1.4 million in personal costs, includes spending on cigarettes, medical costs and lower wages brought on by smoking and exposure to secondhand smoke

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Ethionamide requires activation by the mycobacterial enzyme flavin monooxygenase (EthA) and the transcriptional repressor EthR to form ethionamide sulfoxide, which binds to NAD + and inhibits the enoyl-acyl carrier protein reductase (InhA), thereby blocking mycolic acid synthesis, responsible for cell death (Dover et al., 2007)

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