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P-gp knockout mice ( Tobacco Smoke and Electronic Cigarette Vaping on Exacerbation of Ischemic Stroke Pathophysiology of Ischemic Stroke The prevalence of stroke, a debilitating central nervous system disorder impacting brain arteries that supply the brain with nutrients, continues to be identified as the fifth leading cause of mortality and severe long-term or lifelong disability throughout the US (Virani et al., 2021)