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With regards to prior and concomitant therapies, medications (prescribed or non-prescribed, including antacids, analgesics, herbal remedies, vitamin supplements and minerals) deemed necessary for the subjects safety and wellbeing could be given at the discretion of the Investigator during the residential period

Besides, several studies have indicated that sustained exposure to cigarette smoke is an indicator of epigenetic reprogramming at a global level by measuring the methylation of repetitive elements, such as those of Sat2 20 and LINE-1 21

A slimmer smoke fits on one end, and a thicker one in the other (how smart is that!?)