preferred or dupilumab for moderate-severe allergic asthma with 1 OCS exacerbation/year Eosinophilic (eos 300 cells/L): Mepolizumab (Nucala, anti-IL5), benralizumab (Fasenra, anti-IL5R), reslizumab (Cinqair IV, anti-IL5), or dupilumab (anti-IL4R/IL-13) Mixed/Broad T2: Dupilumab (atopic dermatitis or EoE comorbidity preferred) or tezepelumab (Tezspire, anti-TSLP efficacy across all phenotypes including T2-low) Aspirin-exacerbated respiratory disease (AERD): Dupilumab preferred
Thankfully, weve seen some positive changes over the past few years
Smoking also elevates the risk for coronary heart disease (2-4x), stroke (2-4x), and lung cancer (25x)
Since more than half of Japan Tobaccos revenues are generated from its overseas operations, the company needed to take action to remove potential risks for its flagship brand, including ossible sales bans in certain countries