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Vape juices vary and may contain largely unregulated elements, but studies are showing that they have negative health consequences, including: Immune system depression: Just as smoking decreases the gene expression of some genes that fight viruses and bacteria, vaping affects even more of them

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Sci Total Environ 769:144864 Torkashvand J, Godini K, Norouzi S, Gholami M, Yeganeh M, Farzadkia M (2021b) Effect of cigarette butt on concentration of heavy metals in landfill leachate: health and ecological risk assessment

That's why many clinicians and patient educators describe vaping as a harm-reduction choice rather than a harmless one