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The following formula illustrates how CMS would calculate the AnMP for a Part D rebatable drug as proposed in 428.202(b): (AMP for calendar quarter beginning October) multiplied by (sum of monthly units for October calendar quarter divided by total units for 12-month applicable period) + (AMP for calendar quarter beginning January) multiplied by (sum of monthly units for January calendar quarter divided by total units for 12-month applicable period) + (AMP for calendar quarter beginning April) multiplied by (sum of monthly units for April calendar quarter divided by total units for 12-month applicable period) + (AMP for calendar quarter beginning July) multiplied by (sum of monthly units for July calendar quarter divided by total units for 12-month applicable period) In 428.202(b)(2), CMS proposes that the first applicable period for a Part D rebatable drug will be the earliest applicable period that follows the payment amount benchmark period identified in proposed 428.202(c)(1) through (4)

This disorder often co-occurs with psychiatric disorders and is influenced by risk factors like environmental triggers and nicotine dependence

The implementation costs or negative unintended consequences associated with a cost measure outweigh the benefit of its continued use in the MIPS cost performance category

To do this, in collaboration with Prof Diana Kuh (UCL Epidemiology & Public Health) and her team, they analysed buccal samples from 790 women all born in 1946 and 152 matched blood samples from the Medical Research Council National Survey of Health and Development