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Steatosis progresses to necroinflammation leading to hepatocarcinogenesis as a consequence of multiple parallel acting conditions such as insulin resistance, hyperinsulinemia, dyslipidemia, adipose tissue remodeling, oxidative/endoplasmic reticulum (ER) stress, altered immune system, genetic alterations, and dysbiosis in the gut microbiome

doi: 10.3389/adar.2023.11628 Received 30 May 2023 Accepted 28 July 2023 Published 11 August 2023 Volume 3 - 2023 Edited by Jenny Wilkerson, Texas Tech University Health Sciences Center, United States Reviewed by Kaytlin Krutsch, Texas Tech University Health Sciences Center, United States Elizabeth Yen, Tufts University, United States Updates Copyright 2023 Wells and Lotfipour

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