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Based on varenicline characteristics and clinical experience to date, CHANTIX has no clinically meaningful pharmacokinetic drug interactions [see Clinical Pharmacology (12.3)]

Eur Heart J 40(4):354356 Munzel T et al (2020) Effects of tobacco cigarettes, e-cigarettes, and waterpipe smoking on endothelial function and clinical outcomes

For former heavy smokers taking CYP1A2-metabolized drugs, dose adjustments after cessation are essential to avoid elevated drug levels and adverse drug reactions (ADRs)

[10] In 1950, Richard Doll published research in the British Medical Journal showing a close link between smoking and lung cancer