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The dangers of smoking Smoking is notoriously bad for your health, and according to the NHS is one of the biggest causes of death and illness in the UK

Nicotine also binds 42, a high-affinity receptor along GABA neurons, which, with chronic nicotine use, become desensitized, therefore dampening the inhibition on dopaminergic transmission from the VTA to the NAc, while 7, low-affinity nAChRs on glutamatergic neurons are less prone to desensitization, therefore continue to enhance dopamine transmission (94, 95)

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Nortriptyline, which was evaluated in 6 trials, was the only antidepressant besides bupropion that was superior to placebo