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Scientific Rationalization A true breakthrough came in 1948, when the British epidemiologist Richard Doll published the first major studies that demonstrated that smoking could cause serious health damage
[20] Definition [edit] Nicotine dependence is defined as a neurobiological adaptation to repeated drug exposure that is manifested by highly controlled or compulsive use, the development of tolerance, experiencing withdrawal symptoms upon cessation including cravings, and an inability to quit despite harmful effects
A new review of more than 300 prior studies has identified the best tools to quit smoking
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