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Patients at an increased risk of withdrawal adverse reactions after benzodiazepine discontinuation or rapid dosage reduction include those who take higher dosages (i.e., higher and/or more frequent doses) and those who have had longer durations of use (see WARNINGS, Dependence and Withdrawal Reactions)

When English colonists returned and introduced tobacco to England in the 1580s, they began producing pipes modeled after those brought back from Early America

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