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It's real tobacco, just heated instead of burnt
Grossi S G, Genco R J, Machtei E E
Bull Durham tobacco, to be clear, was not produced as cigarettes - cigarettes were "roll your own." Tobacco was placed in cotton bags manufactured and strung at the Golden Belt Hosiery Mill, which Carr formed in 1887 for the particular purpose of manufacturing tobacco bags
It is strongly associated with the development and progression of hepatic steatosis, increased oxidative stress, mitochondrial dysfunction, activation of pro-inflammatory and pro-fibrotic pathways, and systemic metabolic dysregulation
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