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In addition, stimulation of the VTA by nicotine has a regulating effect on serotonin release in the dorsal raphe mediated by inhibitory GABergic interneurons ( Figure 1 These potential benefits of smoking, however, are contrasted by more severe detrimental effects

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The breakpoints between the categories were selected based on a review of the health effects evidence that is part of the regular review of the National Ambient Air Quality Standards (NAAQS)