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The fact that i) these 8 patients were diagnosed years ago [12], ii) none of them originally experienced major vascular events (1 individual with the COL1A1 variant showed aortic ectasia, uncomplicated tortuous vertebral arteries, and left ventricular thickening), and iii) all underwent periodical vascular surveillance that resulted negative at the time of writing, suggests that the supposed genotype-phenotype correlations of these variants should not be considered valid in all cases

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Also, 33 per cent reported seeing someone smoking in health facilities, while two-thirds of respondents saw someone smoking in university buildings, while 32 per cent reported seeing smoking in schools and 62 per cent saw smoking on public transport