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This theoretical expectation of at least one of the relative and absolute smoking-mortality associations changing over time is supported by recent longitudinal studies of the tobacco epidemic that report increasing relative rates of mortality in current-smokers compared to never-smokers over several decades 7,8,9,10

(Previous research has found that lung cancer risk, by contrast, decreases proportionally depending on the number of cigarettes smoked per day.) The researchers examined 141 previous studies, reported in 55 publications, analyzing the risks of heart disease and stroke among men and women who smoked

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