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Part of the observed efficacy of e-cigs in this study may be related to the fact that they allowed to maintain relatively high blood nicotine levels and showed an excellent experienced benefits/complaints ratio, especially in comparison with continued tobacco smoking

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A follow-up government statement , issued on 27th March, added that although these products [heated tobacco] promote themselves as less risky, to date no independent study has demonstrated that they are harmless to health

One such region adversely affected by nicotine within the adolescent brain is the limbic system, which modulates drug reward, cognition, and emotion [31]