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Public Health Service Clinical Practice Guideline for treating tobacco use and dependence (Fiore et al., 2000): Anxiolytic agents (buspirone, diazepam) may reduce anxiety associated with nicotine withdrawal, but these agents have not been shown to improve quit rates

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As such genetic variants are randomly distributed across the population and are not changed by factors such as alcohol consumption, income, exercise or other health issues the approach is a type of natural experiment that reduces the chances of any link being down to other factors

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