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Chewing of tobacco is injurious to health

Therefore, we are not proposing to establish an average typical dose different than 100 mg for injectable buprenorphine administered on a monthly basis for purposes of calculating the drug component under the OTP benefit, though we seek comment on whether this average typical dose (100 mg) is close to the dose for the monthly formulation of Brixadi that patients receive on average

It was initially thought of as harmless because the tobacco is smokeless and people assumed that simply chewing it wouldnt cause any problems

The burden attributable to high alcohol use also exhibited significant geographic variation