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Intercellular mitochondrial transfer occurs via mechanisms including tunneling nanotube formation between two spatially separated cells, secretion of extracellular vesicles containing mitochondria, gap junctions, and cell fusion where cells will share organelles and cytosolic compounds (172)

The final PM 2.5 concentration estimation is the prediction from the second-layer model plus the prediction from the third-layer model

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arthralgias, aseptic necrosis of femoral and humeral heads, increase risk of fracture, loss of muscle mass, muscle weakness, myalgias, osteopenia, osteoporosis (see PRECAUTIONS: Musculoskeletal), pathologic fracture of long bones, steroid myopathy, tendon rupture (particularly of the Achilles tendon), vertebral compression fractures