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Such a limitation is unavoidable: comparisons between different methods to estimate smoking-attributable mortality did not reveal a best-practice method [46, 47], and even if good estimates of smoking prevalence are available to potentially directly estimate smoking-attributable mortality, other factors like smoking intensity are often harder to measure and to take into account in direct estimates

The Bottom Line As nicotine and cotinine tests are not just confined to standard testing procedures for diagnostic and monitoring purposes, medical laboratories continuously improve to make them more sensitive and accurate

Moreover, it highlights the need for ongoing research into more effective treatments with fewer side effects to enhance the quality of life for patients battling this devastating disease

The bigger issue is that depression, like many other diseases, probably has multiple causes that can augment each other