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Patients with serious psychiatric illnesses such as schizophrenia, bipolar disorder, and major depressive disorder did not participate in premarketing studies of varenicline, and the safety and efficacy of this drug in these patients has not been established

Critics point out that some smokers use both e-cigarettes and cigarettes, negating the benefits that switching might bring

Combining a slow-acting NRT, such as patches, with fast-acting options, like gum or lozenges, can provide effective relief from sudden cravings

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