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What to Expect From a Colonoscopy Prep Pregame It Many doctors may require you to follow a strict clear liquid diet only for one full day before you begin your actual prep, but some say you should start making changes a few days before that in order to take away the stress of a less-than-ideal prep and get the best colon clean-out possible, says Christine Lee, MD, a gastroenterologist at the Cleveland Clinic in Ohio

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