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As reinnervation in the SNL model often results in neuroma formation (Toia et al., 2015), the SNL and tibial nerve crush models, in which the effective nerve regeneration can be observed, were used

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Interestingly, it should be noted that the data from the present study revealed substantial mitochondrial remodeling and elevated oxidative stress, which can amplify the stimulation of group III/IV afferents and increased the susceptibility to muscle fatigue thus providing an alternative mechanism by which exercise intolerance develops in these patients (16, 17)

Then, 370 L of MeOH, 450 L of MTBE and 680 L of H 2 O were added